Genomic homology of ORF 5 gene sequence between modified live vaccine virus and porcine reproductive and respiratory syndrome virus challenge isolates is not predictive of vaccine efficacy
نویسنده
چکیده
Objective: To test the efficacy of Ingelvac PRRS ATP (Boehringer Ingelheim Vetmedica Inc, St Joseph, Missouri), a modified live virus (MLV) vaccine, to protect against respiratory disease and lesions induced by challenge of growing pigs with one of three porcine reproductive and respiratory syndrome virus (PRRSV) field isolates (SDSU73, VR2385, and Mn-01-A1). On the basis of genome sequencing of open reading frame (ORF) 5, these three isolates vary considerably from each other (72% to 86% homology) and from the Ingelvac PRRS ATP vaccine (76% to 89% homology).
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